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P2X7受体在炎症反应中的调节作用 被引量：3

The regulatory roles of P2X7 receptor in inflammation
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摘要 P2X7受体是对二价阳离子有较强选择性的ATP门控的离子通道,参与细胞信号转导,介导细胞毒性作用,活化并诱导宿主细胞凋亡。近几年研究表明,P2X7受体参与炎症反应中细胞因子的释放,特别是P2X7受体活化可促进单核细胞的血管内皮生长因子的释放,该释放依赖钙离子内流与活性氧的产生。本文综述了P2X7受体与炎症细胞及血管内皮生长因子分子机制的相关研究。 P2X7 receptors are ATP-gated ion channels, which has strong selectivity for the divalent cations. P2X7 receptors participate in cell signal transduction, involve in cell-mediated cytotoxicity and activation; while, P2X7 receptor is involved in cytokine release, inflammation, apoptosis and is closely related with the tumor. Although the proinflammatory actions of P2RX7 are well recognized, little is known regarding the potential function of P2RX7 in repair responses. In recent years, researchers found that P2RX7 activation promotes the robust release of vascular endothelial growth factor from primary human monocytes. This vascular endothelial growth factor release is calcium dependent and associated with reactive oxygen species production. This paper reviews the P2X7 receptor biology and its molecular mechanism of inflammatory cell and VEGF releasing.
作者 神谢静 韩莉
机构地区 三峡大学医学院微生物学教研室
出处 《免疫学杂志》 CAS CSCD 北大核心 2013年第1期70-73,共4页 Immunological Journal
基金 湖北省自然科学基金(2009CDZ024) 三峡大学硕士学位论文培优基金(2012PY049)
关键词 P2X7受体 炎症反应 血管内皮生长因子 单核细胞 活化氧 P2X7 receptor Inflammation Vascular endothelial growth factor Monocytes Reactive oxygen species
分类号 R392.12 [医药卫生—免疫学]
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参考文献28

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共引文献33

同被引文献22

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引证文献3

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免疫学杂志
2013年 第1期

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