介入治疗对冠心病血浆MCF-1和TNF-α的影响

Influence of Plasma Monocyte Chemotactic Factor-1(MCF-1) and Tumor Necrosis Factor α(TNF-α) on Interventional Therapy in Patients with Coronary Artery Disease

目的探讨介入治疗对冠心病患者血浆单核细胞趋化因子-1(MCF-1)、肿瘤坏死因子α(TNF-α)及术后再狭窄的影响。方法选择经冠状动脉(冠脉)介入治疗单支病变的冠心病心绞痛患者70例(介入组),包括不稳定型心绞痛38例,稳定型心绞痛32例;冠脉造影结果正常的受试者40例作为对照组。采用酶联免疫吸附法检测对照组及介入组治疗前后MCF-1和TNF-α水平并进行比较。结果治疗前后血浆MCF-1介入组分别为(19.49±4.64)pg/L、(21.99±4.71)pg/L,差异有统计学意义(P<0.01);对照组分别为(17.78±4.42)pg/L、(18.41±4.45)pg/L,差异无统计学意义(P>0.05)。治疗前后血浆TNF-α介入组分别为(15.60±4.89)μg/L、(19.96±5.01)μg/L,差异有统计学意义(P<0.01);对照组分别为(13.50±5.56)μg/L、(14.05±5.68)μg/L,差异无统计学意义(P>0.05)。介入组治疗前后血浆MCF-1、TNF-α水平均显著高于对照组,差异有统计学意义(P<0.05)。结论冠脉介入治疗促进冠心病心绞痛患者血浆MCF-1及TNF-α水平的升高,是否为介入治疗术后支架内再狭窄的重要机制之一尚待进一步论证。

Objective To investigate influence of monocyte chemotactic factor-1（MCF-1） and tumor necrosis factor α（TNF-α） on percutaneous coronary interventional procedures（PCI） in patients with coronary artery disease（CAD） and postoperative vascular restenosis.Methods Seventy patients（therapy group） underwent PCI procedures for CAD compromising a single coronary artery.Among CAD patients there were 38 patients with unstable angina pectoris and 32 with stable angina pectoris.40 healthy people with normal findings by coronary angiography were selected as the control group.Before and after PCI or coronary angiography,levels of plasma MCF-1 and TNF-α were detected and compared between the two groups by enzyme-linked immunosorbant assay（ELISA） respectively.Results The level of plasma MCF-1 in therapy group was significantly elevated after PCI（21.99±4.71） pg/L compared with that of the preoperative level（19.49±4.64） pg/L（P0.01）,whereas in the control group the level of MCF-1 was not statistically significant after coronary angiography（18.41±4.45） pg/L compared with that of the preoperative level of（17.78±4.42） pg/L（P0.05）.PCI procedures also resulted significantly in plasma TNF-α level in the CAD patients after treatment（19.96±5.01） μg/L and the preoperative level of（15.60±4.89） μg/L（P0.01）,but in the control group,TNF-α showed no significant variation after coronary angiography（14.05±5.68） μg/L and the preoperative level of（13.50±5.56） μg/L（P0.05）.Plasma MCF-1 and TNF-α levels in therapy group before and after treatment were significantly higher than those of control group（P0.05）.Conclusion Plasma MCF-1 and TNF-α levels are elevated in CAD patients following PCI procedures,but effect in the vascular restenosis following the procedures need further investigation.