利培酮与氯氮平治疗精神分裂症阴性症状临床对照分析

A control study of risperidone and clozapine in the treatment of the negative symptoms of schizophrenia

目的 :以氯氮平作对照研究利培酮对精神分裂症阴性症状的疗效。方法 :利培酮 ,氯氮平治疗 4 0例以阴性症状为主型的精神分裂症病人 ,以阴性症状评定量表 (SANS)得分结果来评定疗效 ;以副反应量表 (TESS)得分情况评价治疗中出现的副反应。结果 :两组在治疗前后SANS总分相比均显著降低 (P <0 0 5) ;TESS总分 ,利培酮组明显低于氯氮平组 (P <0 0 1)。结论

OBJECTIVE:To compare the therapeutic effect of risperidone and clozapine on the negative symptoms of schizophrenia.METHODS:Twenty schizophrenic patients were treated with risperidone and tewnty schizophrenic patients with clozapine. Both were assessed with the SANS and TESS, double blind, before and after treament to evaluate the effects on negative symptoms. RESULT:Both drugs were effective in treating the negative symptoms of schizophrenia (p>0 05). While risperidone has fewer side effects than clozapine. CONCLUSION:Clozapine's superior effect on negative symptoms of schizophrenia may be related to its affinity to 5-HT receptors. So is risperidone. And risperidone's fewer side effects may be related to its equal affinity to 5-HT and DA receptors.