胰腺区域动脉持续性灌注奥曲肽对犬重症胰腺炎的影响

Effect of continuous regional intraarterial infusion of octreotide on canine acute necrotizing pancreatitis

目的 观察胰腺区域动脉持续性灌注奥曲肽对犬实验性急性坏死性胰腺炎 (acutenecrotizingpancreatitis,ANP)的治疗作用。方法 经胰管开口逆行注入 5 %的牛磺胆酸钠诱导ANP模型 ,犬胰腺区域动脉灌注采用经颈动脉插管、腹腔干动脉持续灌注。 30只杂种犬随机分成 3组 :对照组 (A组 )、奥曲肽皮下注射组 (B组 )和持续性胰腺区域动脉灌注奥曲肽组 (C组 )。结果 模型诱导成功后 2 4h ,C组与A组平均血清淀粉酶分别为 132 9U/L和 32 40U/L ;平均血清脂肪酶分别为 438U/L和 2 0 34U/L ,两组相比较差异有显著意义 (P <0 0 5 )。C组术后 12h、2 4h红细胞压积分别为44 7%、40 4% ,A组为 5 4 3%、5 0 2 % ,不同时间两组比较差异均有显著意义 (P <0 0 5 ) ;B组红细胞压积与A组比较无显著意义 (B组红细胞压积分别为 5 1 6 %、47 2 % )。C组术后 2 4h的大体及光学显微镜下各项病理学评分结果与A组比较 ,差异均有显著意义 (P <0 0 5 ) ;B组病理学各项指标的改善程度没有C组明显。结论 持续性胰腺区域动脉灌注奥曲肽对急性坏死性胰腺炎有良好的治疗作用。

Objective[WT5”BZ] To observe the effect of continuous intraarterial infusion of octreotide on canine acute necrotizing pancreatitis(ANP). [WT5”HZ] Methods [WT5”BZ] Sodium taurocholate was injected into the main pancreatic duct to induce canine ANP model.Thirty dogs were randomly divided into three groups;Group A: control group,Group B: octreotide was administrated subcutaneously in a dosage of 8?μg·kg -1 ·d -1 beginning 1 hour after the induction of pancreatitis,Group C: octreotide was given via celiac artery continuously.[WT5”HZ]Results[WT5”BZ] 24 hours after induction of the ANP models,the average serum amylase in group C and group A were 1?329 and 324 U/L respectively,while the average serum lipase were 438 and 2?034 U/L (all P <0 05).Hematocrit,gross and histologic pathologic scoring were significantly less severe in group C than in group A ( P <0 05).Clinical and pathological parameters in group B was not as favorable as in group C. [WT5”HZ] Conclusion[WT5”BZ] Continuous intraarterial infusion of octreotide is a very effective method in the treatment of ANP. [WT5”HZ]