益生菌在根除幽门螺杆菌感染中的临床价值

The Clinical Value of Probiotics in the Treatment of Helicobacter Pylori Infection

目的探讨益生菌在根除幽门螺杆菌(Hp)感染中的临床价值。方法选择2011年1月至2012年8月我院收治的慢性胃炎患者102例,随机分为治疗组和对照组,每组51例。对照组给予四联疗法,治疗组采用益生菌联合四联疗法。结果在治疗后,治疗组Hp根除率、治疗有效率均显著高于对照组(90.2%vs.70.6%,92.2%vs.76.5%,P均<0.05),而不良反应的发生率则显著低于对照组(11.8%vs.27.5%,P<0.05)。结论益生菌能有效提高四联疗法的Hp根除率,改善患者临床症状,减少药物副反应。

Objective To explore the clinical value ofprobiotics in treating Helicobacter pylori （Hp） infection. Methods 102 patients with chronic gastritis treated in our hospital from January 2011 to August 2012 were randomly divided into therapy group and control group. Both groups received quadruple Hp-eradicational therapy, in addition, the therapy group was treated with orally probiotics. Results The rate of lip-eradication and effectiveness in therapy group were significantly higher than those ＆the control （90.2% vs. 70.6%, 92.2% vs. 76.5%, both P 〈0.05）, but the incidence of side effects in therapy group was much lower than that of the control （11.8% vs. 27.5%, P 〈0.05）. Conclusions The probiotics can effectively enhance the rate of Hp-eradication of quadruple Hp-eradicational therapy, improve the clinical symptom and decrease the incidence of side effects.