老年患者血压水平与颈动脉粥样硬化的相关性研究

Levels of Blood Pressure in Elderly Patients with Hypertension:Associated with Carotid Atherosclerosis

目的探讨老年高血压患者血压水平与颈动脉粥样硬化的关系。方法将患有原发性高血压120例年龄>60岁的患者,将患者根据收缩压分组:血压严格控制组(血压<130mmHg),血压一般控制组(血压130～139mmHg)。对每位患者进行颈动脉超声检查,记录颈动脉内中膜层的厚度。结果多因素线性回归分析显示,收缩压、总胆固醇、空腹血糖与颈动脉颈动脉内中膜厚度呈正相关,而高密度脂蛋白胆固醇与颈动脉颈动脉内中膜厚度呈负相关。分析显示,收缩压≥140mmHg、总胆固醇为颈动脉粥样斑块形成的危险因素,而高密度脂蛋白胆固醇为其保护性因素。结论血压水平和颈动脉粥样硬化具有显著的相关性,血压水平是老年患者颈动脉粥样硬化及斑块形成的危险因素之一。

Objective To explore the association between blood pressure and carotid atherosclerosis in elderly patients with primary hypertension. Methods A total of 120 patients aged 60 years or over with primary hypertension were recruited and categorized by their systolic blood pressure （SBP）： tight control, 〈130 rnm Hg, usual control, 130 - 139 mm Hg; Carotid ultrasonography was performed in all subjects for the evaluation of intima-media thickness （1MT） and plaque. Results Multiple linear regression analysis revealed that systolic blood pressure, total cholesterol, fasting blood glucose and carotid carotid intima thickness was positively correlated, and high-density lipoprotein cholesterol with carotid carotid intima thickness was negatively correlated. The analysis showed that the systolic blood pressure ≥ 140 mm Hg, total cholesterol were the risk factors for carotid plaque formation, and high-density lipoprotein cholesterol was the protective factor. Conclusions There is a significant correlation between the levels of blood pressure and carotid atherosclerosis. Blood pressure level is one of the risk factors of carotid atherosclerosis and plaque formation in elderly patients.