摘要
小窝蛋白-1是小窝的主要的结构组成部分。小窝蛋白-1调节关键的细胞功能,包括增殖、凋亡、细胞分化及细胞信号转导。在肺的各种细胞几乎都富含小窝蛋白-1,包括:Ⅰ型上皮细胞,内皮细胞,平滑肌细胞,成纤维细胞,巨噬细胞,中性粒细胞。小窝蛋白-1在急性肺损伤的发病过程中发挥了至关重要的作用。本文将对小窝蛋白-1在急性肺损伤方面的调控与功能进行总结。
Cav-1 is the principal structural component of caveolae. Cav-1 regulates critical cell functions including proliferation, apoptosis, cell differentiation, and transcytosis via diverse signaling pathways. Abundant in almost every cell type in the lung, including type I epithelial cells, endothelial cells, smooth muscle cells, fibroblasts, macrophages, and neutrophils, Cav-1 plays a crucial role in the pathogenesis of acute lung injury （ALI）. In this article, we summarized the recent data regarding the regulation and function of Cav-1 in lung biology and pathology, in particular as its relation to ALI.
出处
《临床医学工程》
2012年第12期2286-2288,共3页
Clinical Medicine & Engineering
