摘要
对国内首次研制的多价钩端螺旋体外膜疫苗接种人体安全性和免疫效果进行研究。 10 73名易感青少年随机接种钩端螺旋体三价 (含黄疸出血群赖型、七日热群七日热型、流感伤寒群流感伤寒型 )外膜疫苗、五价 (含黄疸出血群赖型、七日热群七日热型、流感伤寒群流感伤寒型、秋季热群秋季热型、犬群犬型 )外膜疫苗、菌体疫苗和安慰剂 ,分组进行全身和局部的反应观察 ,并以显微镜凝集试验测定各型抗体。结果显示各疫苗组局部和全身反应轻微。三价和五价外膜疫苗免后 1个月和 3个月抗体滴度高于同期相应菌体疫苗诱导的同型抗体滴度 ;且免后 3个月抗体阳转率也较高。提示外膜疫苗较菌体疫苗有更好的免疫原性。
A randomized trial was conducted to evaluate the safety and immunogenisity of trivalent and pentavalent Leptospira outer membrane vaccine 1073 healthy adole-scent who had negtive response to Leptospira were immunized with outer membrane vaccine,Leptospira whole cell vaccine and placebo Both vaccines were well tolerated The local and systemic reaction were mind The GMT for those immunized Leptospira outer membrane vaccine was significantly(P<0 01)higher compared with recipients of Leptospira whole cell vaccine
出处
《中国人兽共患病杂志》
CSCD
北大核心
2000年第3期38-40,共3页
Chinese Journal of Zoonoses
关键词
钩端螺旋体外膜疫苗
安全性
免疫效果
Leptospira outer membrane vaccine
Leptospira whole cell vaccine
Safety
Immunized
