阿奇霉素联合炎琥宁与单用阿奇霉素治疗儿童支原体肺炎的对比分析

Azithromycin combined with potassium sodium dehydroandroan drographolide succinate versus azithromycin alone for mycoplasma pneumonia in children

目的对比分析阿奇霉素联合炎琥宁与单用阿奇霉素治疗儿童支原体肺炎的疗效。方法选取我院收治的儿童支原体肺炎患者94例，随机分为观察组和对照组各47例。所有患儿均给予一般支持治疗及化痰、止咳、退热等对症治疗。对照组患儿在此基础上应用阿奇霉素治疗，观察组患儿给予阿奇霉素联合炎琥宁治疗。所有患儿均接受治疗2个疗程。结果观察组患儿应用阿奇霉素联合炎琥宁治疗后，患儿退热时间、咳嗽消失、肺部体征消失及肺部X线恢复时间均较对照组显著缩短（P〈0．01）；所有患儿接受2个疗程治疗后，观察组患儿治疗总有效率为95．7％，显著高于对照组（80．9％），P〈0．05。结论阿奇霉素联合炎琥宁较单用阿奇霉素治疗小儿支原体肺炎起效快，疗效好，值得临床推广应用。

Objective To compare the efficacy of azithromycin combined with potassium sodium dehydroandroan drographolide succinate （ PSDDS ） with that of azithromycin alone for mycoplasma pneu- monia in children. Methods 94 children with mycoplasma pneumonia were randomly into study group and control group, 47 for each group. All the children received supporting therapy and symptomatic treatment. The control group received additional azithromycin alone while the study group were treated with azithromycin plus PSDDS. Results Time to fever relief, time to cough relief, time to disappearance of chest signs, and time to restoration of chest X-ray appearance were significantly shorter in the study group than in the control group （ P〈 0.01 ）. After 2 courses of treatment, the total effectiveness rate was significantly higher in the study group than in the control group （ 95.7% vs. 80.9%, P 〈 0.05 ）. Conclusions Azithromycin combined with potassium sodium dehydroandroan drographolide succinateis has a faster action of onset and is more efficacious than azithromycin alone in the treatment of mycoplasma pneumonia in children.