右美托咪定对开胸术患者全麻苏醒期躁动及循环的影响

Effects of Dexmedetomidine on Anesthesia Emergence Agitation and Circulation of Patients with Sternal Closure

目的观察右美托咪定对肺癌根治术患者全麻苏醒期间躁动及循环影响。方法根据美国麻醉师协会(ASA)体格情况分级选择40例Ⅰ～Ⅱ级择期行肺癌根治术的患者,随机分为右美托咪定组(观察组)和对照组,观察组在手术关胸前经微泵持续静脉输注右美托咪定1μg/kg(4μg/ml),输注时间为15min,对照组持续输注同等容量生理盐水。观察两组在苏醒期躁动及循环情况。结果观察组术后躁动发生率(10%)显著低于对照组(40%),差异有统计学意义(P<0.05),围拔管期各时点的血压、心率等均显著低于对照组,差异有统计学意义(P<0.05或P<0.01)。结论右美托咪定可使肺癌根治术患者全麻苏醒期的躁动减少,维持血流动力学稳定。

Objective To investigate the effects of single-dose of dexmedetomidine following sternal closure on the agitation and circu- lation in patients with pulmomonary carcinoma undergoing lung resection. Methods Forty ASA （American Society of Anesthesiolo- gists）Ⅰ ～ Ⅱ patients who were scheduled for radical resection of pulmomonary carcinomawere that randomly divided into two groups to receive 1 pg/kg （4/xg/ml） dexmedetomidine （observation group） or saline solution （control group） before the sternum closing. Record the SBP, DBP, HR, Restlessness Score （RS） during the recovery period. Results There was a significant difference in the incidence of emergence agitation between observation group and control group when endotracheal tube was removed （ P 〈 0.05）. There was a significant difference in the blood presure, heart rate between these two groups at the time of extubation, as well as at 5 rain and 10 rain following extubation （ P 〈 0.05）. Conclusions Using Single-dose of dexmedetomidine before the sternum closing can relieve restlessness and modify cardiovascular response after general anesthesia on the patients with radical resection of pulmomonary carcinoma.