甘糖酯对充血性心力衰竭患者血清肿瘤坏死因子-α浓度的影响及其意义

THE INFLUENCE AND ITS SIGNIFICANCE OF PGMS TO SERUM TUMOR NECROSIS FACTOR-α IN PATIENTS WITH CONGESTIVE HEART FAILURE

目的：为探讨甘糖酯（PGMS）在治疗慢性充血心力衰竭（CHF）中的作用。方法：将40例CHF患者随机分为两组。PGMS组（20例）在常规治疗心衰的基础上加用PGMS100mg，tid，2w后与常规心衰组（20例）进行比较。结果：在PGMS组，CHF患者血清肿瘤坏死因子-α（TNF-α）浓度降低较常规组显著（P＜0．05），且左室射血分数明显改善（P＜0．05）。提示：PGMS在治疗CHF过程中，可通过对机体内TNF-α浓度的调节，发挥其降低血液黏度、保护血管内皮细胞功能和抑制脂质过氧化物生成的作用。

Objective:In order to investment the value of Proplylene glucol mannurate sulfate (PGMS) ln the treatment of congestive heart failure (CHF). Methods: 40 patients with CHF were dlvided into 2 groups randomly. In addition to normal treatment, 100mg PGMS was given to PGMS group,tid. After two weeks treatment,PGMS group was compared with controlled. Results: In PGMS group, the serum level of tumor necrosis factor-α (TNFα) reduced greatly (P<0.05 )and the left ventricular eject fraction (LVEF)improved greatly (P<0.05)than that Qf controlled group' Conclusion: During the treatment of CHF,PGMS can reduce blood viscosity,protects the integral of blood vessel endodermis and resists the LPO.