垂体腺瘤中癌基因蛋白的表达

Expression of Oncoprotein in Pituitary Adenomas

目的 探讨癌基因蛋白在垂体腺瘤发生过程中的作用及表达。方法 对 30例垂体腺瘤进行了 c- erb B-2、c- myc、bcl- 2及 P2 14种癌基因表达蛋白的免疫组织化学检测 ,并与其功能分类进行了观察比较。结果 4种癌基因蛋白的阳性率分别为 93.4% ,46 .7% ,2 0 % ,6 .7%。结论 尽管垂体腺瘤在组织形态学上多表现为良性肿瘤的特征 ,但在肿瘤的发生和演进过程中 ,其与癌基因扩增及表达与之具有密切关系。癌基因蛋白的表达与功能分类的比较观察表明

Objective To investigate the expression of oncoproteins in pituitary adenomas.Methods Four kinds of oncoprotein:c erbB 2,c myc,bcl 2 and P21 were examined in 30 cases of pituitary adenomas by immunohistochemical methods.Results The positive rates of these oncoproteins were 93.4%,46.7%,20.0% and 6.7% respectively.Conclusion These studies suggest that the expression and amplification of oncogene play an important role in the progression of pituitary tumor although the tumor shows adenoma structure in histopathology.