摘要
目的研究延胡索乙素的体内药物动力学。方法建立延胡索乙素的体内方法,并进行方法学考察,分别尾静脉和灌胃给药,进行延胡索乙素体内药物动力学研究。结果建立的方法学可靠,延胡索乙素在体内表现为单室模型,绝对生物利用度低。结论有必要对延胡索乙素进行促吸收的研究。
OBJECTIVE To investigate the pharmacokinetical process of tetrahydropalmatine in rats.METHODS Tetrahydropalmatine in vivo was established and evaluated by methodology.The rats were administrated through mouth and tail vein.RESULTS The method we created was reliable,mono-compartment was the form of tetrahydropalmatine in vivo,and its absolute bioavailability was low.CONCLUSION It is necessary to carry out the study of promoting absorption of tetrahydropalmatine.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2012年第6期555-557,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
教育部博士点新教师基金(20093237120016)
关键词
延胡索乙素
药物动力学
大鼠
tetrahydropalmatine
pharmacokinetics
rats