广泛性焦虑障碍和惊恐障碍患者情绪Stroop任务功能磁共振研究

Functional magnetic resonance imaging study of emotional Stroop task in patient with generalized anxiety disorder and panic disorder

目的:探讨广泛性焦虑障碍(GAD)和惊恐障碍(PD)患者情绪Stroop任务时的脑功能状态及其差异。方法:对经过美国精神障碍诊断与统计手册第4版修订版(DSM-IV-TR)轴I障碍定式临床检查病人版(SCID-I/P)确诊的5例GAD患者(GAD组)、10例PD患者(PD组)及9名正常对照(正常对照组)完成相关的心理评估,并在规定的时间内进行功能磁共振扫描。结果:功能磁共振结果显示,处理一般焦虑信息干扰时,PD患者和GAD患者均表现出皮质功能不足和皮质下反应增强;处理惊恐/恐惧相关信息干扰时,PD患者仍表现出皮质功能不足。正性词任务时PD患者皮质功能不足,而GAD患者皮质及皮质下激活均增加。结论:GAD与PD患者均存在不同的脑功能差异。

Objective：To investigate brain function during emotional Stroop task in patients with generalized anxiety disorder（GAD） and panic disorder（PD）,and compare the difference between them.Method：10 patients with PD,5 patients with GAD,who confirmed with structural clinical interview for diagnostic and statistical manual of mental disorders,fourth edition,text revision（DSM-IV-TR）,and 9 controls finished related psychological assessment and had functional magnetic resonance imaging（fMRI） scan within the specified time.Results：The results of fMRI showed that patients with PD and GAD both showed decreased recruitment of labor and augmented sub-labor evaluation when dealing with GAD-related stimuli＇s distracting;patients with PD showed decreased labor function when processing the distracting of panic/fear stimuli;patients with PD showed decreased labor function when doing positive words task,while patients with GAD showed increased labor and sub-labor evaluation.Conclusion：GAD and PD patients have different pattern of brain function.