精神分裂症患者事件相关电位P300的对照研究

A control study of event related potential P300 in patients with schizophrenia

目的:探讨精神分裂症患者听觉诱发电位P300的特征及病程对P300的影响。方法:对68例精神分裂症患者(研究组)和30名正常对照(正常对照组)进行事件相关电位P300的检测,并分析比较不同病程对P300的影响。结果:研究组Fz、Cz、FC1的P300潜伏期较对照组明显延迟(t分别=2.67,3.48,3.36;P均<0.01);Fz、Cz、FC1、FC2的波幅较对照组显著降低(t分别=5.97,2.54,4.57,3.80;P均<0.01)。对研究组中病程<6个月组和病程>5年组的患者比较发现,病程>5年组的患者Fz、Cz潜伏期延迟(t=9.23,7.63;P均<0.01),波幅降低(t=11.97,6.66;P均<0.01)。结论:精神分裂症患者认知功能受损,病程越长,受损越重。

Objective：To explore the characteristics auditory evoked potentials of schizophrenia patients and the effect of illness duration on P300.Method：68 cases of schizophrenia patients and 30 cases of normal control group were measured events related potential P300,and the difference of disease progression was compared.Results：The research group had significantly longer latency at Fz,Cz,FC1（t=2.67,3.48,3.36;all P0.01） and lower amplitude at Fz,Cz,FC1 and FC2（t=5.97,2.54,4.57,3.80;all P0.01）.Patients were divided into two groups by illness duration.The latency at Fz,Cz of 5 year illness duration of schizophrenia patients was significantly longer（t=9.23,7.63;all P0.01）.Amplitudes were significantly lower（t=11.97,6.66;all P0.01）.Conclusion：Patients with schizophrenia have cognitive function impairment.The longer the illness duration is,the more congnitive impairment is presented in patients with schizophrenia.