艾司西酞普兰合并脑电生物反馈疗法治疗焦虑障碍

A comparative study of anxiety disorders treatment with escitalopram associated with electroencephalographic biofeedback therapy

目的:探讨脑电生物反馈疗法对焦虑障碍的辅助治疗作用。方法:60例符合焦虑障碍诊断标准的患者随机分为研究组和对照组各30例,均给予艾司西酞普兰治疗6周。研究组同时进行6周(共24次)的脑电生物反馈治疗。于治疗前后分别采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表-病情严重程度(CGI-SI)评定疗效;WHO生存质量测定简表(WHOQOL-BREF)评定生存质量。结果:研究组和对照组显效率分别为78.6%和51.7%(χ2=4.51,P<0.05)。两组HAMA和CGI-SI评分治疗后较治疗前均显著降低(P均<0.05),以研究组下降更为显著(t=-3.880,-2.899;P<0.05)。两组治疗后生存质量4个领域的评分均明显提高(P<0.05),以研究组生理领域评分增加显著(t=-4.712,P<0.05)。结论:艾司西酞普兰合并脑电生物反馈对焦虑障碍的疗效优于单用艾司西酞普兰。

Objective：To explore the assistant effect of electroencephalographic biofeedback therapy in the treatment of anxiety disorders.Method：60 patients with anxiety disorder were randomly divided into study group（n=30） and control group（n=30）.All of them were given treatmeat of escitalopram for 6 weeks,besides,patients in study group accepted 24 times electroencephalographic biofeedback therapy in 6 weeks.The efficacy was assessed with the Hamilton anxiety scale（HAMA） and clinical global impression scale（CGI）,the patients,quality of life was assessed with the WHO quality of life questionnaire（WHOQOL-BREF）before and after treatment.Results：After 6 weeks of treatment,the significant efficacy rates of study group and control group were 78.6% and 51.7% respectively（χ2=4.51,P0.05）.The scores of HAMA and CGI in two groups after treatment were significantly decreased than before treatment（all P0.05）.The scores of HAMA and CGI in study group was reduced more significantly than control group at 6th weekend after treatment（t=-3.880,-2.899;P0.05）.The score in four areas of quality of life were significantly improved after treatment in the two groups（P0.05）,the physiological domain score in study group was increased significantly（t=-4.712,P0.05）.Conclusion：Treating anxiety disorders with escitalopram associated with electroencephalographic biofeedback therapy was better than only with escitalopram.