艾司西酞普兰与舍曲林治疗伴焦虑症状抑郁症患者疗效比较

Escitalopram and sertraline in treatment of depression with anxiety

目的:比较艾司西酞普兰与舍曲林治疗伴焦虑症状的抑郁症疗效和安全性。方法:76例符合入组标准的患者随机分为艾司西酞普兰组和盐酸舍曲林组各38例,疗程6周。用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评定疗效,采用治疗中出现的症状量表(TESS)评定安全性。结果:两组HAMD、HAMA评分均较治疗前显著降低(P<0.01),以艾司西酞普兰组HAMD、HAMA评分在治疗1周时降分显著低于盐酸舍曲林组(t=-2.839,-2.862;P<0.01),其余各周差异无统计学意义(P>0.05)。艾司西酞普兰组与舍曲林组不良反应发生率分别为39.5%和42.1%(P>0.05)。结论:艾司西酞普兰与舍曲林治疗伴焦虑症状的抑郁症疗效相当,但艾司西酞普兰起效更快。

Objective：To evaluate the efficacy and safety of escitalopram and sertraline in the treatment of depression with anxiety.Method：76 of patients with depression with anxiety were randomly assigned to receive escitalopram（n=38） or sertraline（n=38） for up to 6 weeks in this randomized,parallel-group study.The rapeutic efficacy was assessed with Hamilton depression scale（HAMD-17） and Hamilton anxiety scale（HAMA）.Safety profile was assessed with treatment emergent symptom scale（TESS）.Results：The mean values of HAMD-17 and HAMA total scores improved significantly for both groups from the baseline to the end of week 6th（P0.01）.At the end of the first week,the total scores of HAMD and HAMA in the group of escitalopram were significant lower than that of group of sertraline（t=-2.839,-2.862;P0.01）,but there were no statistically significant differences between two groups at the end of week 2,4 and 6th（P0.05）.The incidences of side effects were 39.5% in escitalopram group and 42.1% in sertraline group（P0.05）.Conclusion：The therapeutic effect and side effect on depression with anxiety are not different between escitalopram and sertraline.Escitalopram has earlier response than sertraline.