应用高氧液对大面积烧伤病人T淋巴细胞亚群的影响

The Influence of Application of High Liquid Oxygen on T Lymphocytes subsets in Large Area Burned Patients

目的:探讨高氧液在减轻机体烧伤后缺血缺氧性损害治疗中的作用。方法:将27例大面积烧伤患者随机分成加用高氧液治疗的观察组与常规治疗的对照组2组,分别于受伤后第2天、第7天、第14天、第21天晨抽静脉血采用AP-AAP桥联酶免疫检测法检测T淋巴细胞亚群(CD3+、CD4+、CD8+)。结果:观察组较对照组CD3+、CD4+、CD4+/CD8+值降低程度轻,回升早,恢复快,CD8+增高程度小,恢复快。结论:大面积烧伤病人早期复苏中静脉应用高氧液对重度烧伤患者的T淋巴细胞亚群具有明显调理作用,从而减少MODS的发生率,提高整体治疗效果。

Objective：To explore the effect of hyperoxic fluid treatment in relieving hypoxic -ischemic injury after burn. Methods： 27 patients with large area burn were randomly divided into two group; T lymphocyte subsets （CD3^＋ ,CD4^＋ ,CD8^＋ ） of the venous blood were collected on the 2,7,14,21 day after burn respectively with APAAP ELISA. Results ：The level of CD3^＋ ,CD4^＋ ,CD4^＋/CD8^＋ of hyperoxic fluid group was less decreased than that of normal group ; the level of CDs of hyperoxic fluid group was less increased than that of normal group（ P 〈 0.01 ）. Conclusion：Using hyperoxic fluid in vein can significantly regulate the level of T lymphocyte subsets during early revival of burned patient, decrease the incidence of MODS, improve effect of integrative treatment.