前列地尔与丁咯地尔治疗突发性耳聋的临床比较

Comparison of the Therapeutic Effect of Alprostadil Injection and Buflomedil Injection in Sudden Deafness

目的:对比观察前列地尔与丁咯地尔治疗突发性耳聋的疗效及安全性。方法:将符合纳入标准的80例突发性耳聋患者随机分为2组,前列地尔组40例和丁咯地尔组40例。所有患者均给予银杏叶提取物与能量合剂治疗,在此基础上,前列地尔组予前列地尔注射液10μg加于生理盐水100 mL中静脉滴注,丁咯地尔组予丁咯地尔注射液200 mg加于生理盐水100 mL中静脉滴注。均以10天为1个疗程,观察并比较2组病例的总有效率、耳鸣和眩晕症状恢复情况以及不良反应发生情况。结果:治疗突发性耳聋的总有效率前列地尔组为92.50%,丁咯地尔组为80.00%,2组比较有显著性差异(P<0.05)。前列地尔组耳鸣及眩晕恢复情况亦有显著性差异(P<0.05)。2组在治疗过程中均未观察到心衰、头晕、头痛、局部血管刺激征、静脉炎等不良反应。结论:前列地尔治疗突发性耳聋的疗效优于丁咯地尔,且无明显不良反应,值得临床推广。

Objective ：To observe the therapeutic effect of alprostadil injection and buflomedil injection in patients with sudden deafness. Methods： 80 patients with sudden deafness were divided into two groups randomly. 40 patients （40 ears） in the group were treated with alprostadil injection （10 μg/d, qd）; 40 patients （40 ears） in the buflomedil group were treated with buflomedil injection （200 mg/d, qd）. Both groups were treated with common therapy intravenously, such as energy composition. The time of treatment for both groups was 10 days. The total effective rate, recovery rate of tinnitus and vertigo, side effect were observed and compared between the two groups. Results：The total effective rate of the alprostadil group was higher than that of the buflomedil group, which were 92.5% and 80% respectively（P 〈 0.05）. Recovery rate of tinnitus and vertigo in the alprostadil group was significantly higher than that in the buflomedil group （P 〈 0.05 ）. No side effect was observed in the two groups. Conclusion ： Alprostadil is superior to buflomedil for sudden deafness.