参芝通络胶囊对大鼠长期毒性的实验研究

Long term toxicity in rats of Shenzhi Tongluo Capsule

目的考察参芝通络胶囊对大鼠的长期毒性,为临床用药提供依据。方法 SD大鼠随机分为对照组和参芝通络胶囊高、中、低剂量组(4、2、1g/kg)。ig给药13周,除观察一般状况外,检测体质量、血液学指标、血液生化指标,解剖计算内脏系数并进行病理组织学检查。剩余大鼠停止给药,恢复2周后进行上述相同指标检测。结果参芝通络胶囊各剂量组对大鼠一般状况、体质量、血液学指标、血液生化指标、内脏系数和病理组织学无明显影响,恢复期大鼠上述各指标与对照组比较无明显差异。结论在确定的临床使用剂量下,参芝通络胶囊长期服用无明显毒性。

Objective To observe the long term toxicity in rats of Shenzhi Tongluo Capsule（STC） and to provide the science foundation for clinical administration.Methods Sprague-Dawley rats were randomly divided into four experimental groups：control,high-,mid-,and low-dose STC（4,2,and 1g/kg） groups,and ig administered continuously for 13 weeks.The general conditions were observed and the related indexes were detected,such as body weight,hematological indexes,and blood biochemical indexes.The rats were dissected,the visceral coefficients of body was calculated and the histopathologic examination was performed.The administration to the remaining rats was stopped for recovering for two weeks.The recovery conditions of rats were observed and the above indexes were detected.Results There was no significant effect of STC at different doses on the general conditions,body weight,hematological and blood biochemical indexes,the visceral coefficients of body,and histopathologic examination.There was no obvious difference in the above indexes of recovered rats compared with the control group.Conclusion STC in certain clinical dose has no toxicity for long term use.