左乙拉西坦对癫痫患者认知功能及情绪影响的临床研究

The Clinical Study about Levetiracetam of Cognitive Function and Emotional Influence in the Patients with Epilepsy

目的:探讨左乙拉西坦对癫痫患者认知功能及情绪的临床影响。方法:选择同期癫痫患者60例,随机均分为对照组(n=30例)和观察组(n=30例),对照组患者给予丙戊酸钠治疗,观察组患者给予左乙拉西坦治疗,治疗第4w、8w、12w、16w比较两组患者蒙特利尔认知评估量表(MoCA)、神经电生理P300电位检查、焦虑自评量表(SAS)和抑郁自评量表(SDS)情况。结果:两组患者治疗第4w、第8w、第12w和第16w的MoCA评分和P300电位潜伏期时长比较,差异均具有统计学意义(P<0.05),观察组显著优于对照组;治疗第12w和第16w的SAS评分和SDS评分比较,差异均具有统计学意义(P<0.05),对照组显著优于观察组。结论:在癫痫患者的药物治疗过程中,左乙拉西坦对患者认知功能的改善优于丙戊酸钠,但对情绪的负性影响较丙戊酸钠明显。

Objective： To investigate the clinical influence about Levetiracetam of cognitive function and emotional influence in the patients with epilepsy. Method： 60 patients with epilepsy were collected. 30 patients were divided into the control group treated by Valproate, while 30 patients were divided into the observation group treated by Levetiracetam. MoCA Scale, Neuroelectrophysiological P300 potentials, SAS Scale and SDS Scale was detected at the 4th week＇s, 8th week＇s, 12th week＇s and 16th week＇s treatment. Result： There was significantdifference （P 〈0.05） in the MoCA score and P300 potential latency duration after the 4th week＇s, 8th week＇s,12th week＇s and 16th week＇s treatment, which was better in observation group than in control group. There was significantdifference（P 〈0.05） in the SAS Scale and SDS Scale after the 12th week＇s and 16th week＇s treatment, the control group showed better result than the observation group. Conclusion： In the process of treating the patients with epilepsy by drug, Levetiracetam is superior to Valproate on the improve- ment of cognitive function, but Levetiracetam＇s negative influence on mood was significantly worse than Valproate.