摘要
目的:探讨急性心肌梗死行经皮冠状动脉介入治疗(PCI)血清炎症因子的改变及其与预后的关系。方法:选择126例拟行PCI治疗的急性心肌梗死患者为研究对象,比较PCI手术前后血清超敏C反应蛋白(hs-CRP)及肿瘤坏死因子α(TNF-α)的改变。同时比较PCI术后3月发生心血管事件患者与未发生心血管事件患者术后12h血清hs-CRP及TNF-α的差别。结果:患者PCI术后血清hs-CRP及TNF-α水平均显著升高,与术前相比差别具有统计学意义(P<0.05);PCI术后3月发生心血管事件患者PCI术后12h血清hs-CRP及TNF-α水平显著高于未发生心血管事件患者(P<0.05);Logistic回归结果显示:hs-CRP及TNF-α与心血管事件发生率显著相关。结论:急性心肌梗死行PCI患者术后发生急性炎症反应,hs-CRP及TNF-α水平升高与患者心血管事件发生密切相关,可作为评估预后的血清学指标。
Objective: To explore the change of inflammatory factors in acute myocardial infarction patients who underwent percutaneous coronary intervention and their relationships with prognosis. Methods: Selected 126 cases with acute myocardial infarction patients who would get percutaneous coronary intervention as research subjects. Serum high-sensitivity c-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α) were measured before and after PCI. Hs-CRP and TNF-α level between the patients who had cardio-vascular events and those who had no cardiovascular events in the follow-up period were compared. Results: Serum hs-CRP and TNF-α level greatly increased after PCI as compared with preoperative (P〈0.05); Hs-CRP and TNF-α level on 12 hours after PCI in the patients who had cardiovascular events were much higher than that in those who had no cardiovascular events (P〈0.05); Logistic regression results showed that hs-CRP and TNF-α level had significant correlation with the occurrence ofcardiovascular events (P〈0.05). Conclusions: Acute inflammation occurred in acute myocardial infarction patients after PCI. The high levels ofhs-CRP and TNF-α had close relation-ship with the occurrence of cardiovascular events, so they could be taken as the serological indexes for evaluating prognosis.
出处
《现代生物医学进展》
CAS
2012年第32期6362-6364,共3页
Progress in Modern Biomedicine
基金
新疆维吾尔自治区自然科学基金项目(2010211A34)
关键词
急性心肌梗死
超敏C反应蛋白
肿瘤坏死因子Α
Acute myocardial infarction
High-sensitivity c-reactive protein
Tumor necrosis factorα