人工肝支持系统(ALSS)治疗重型乙肝患者血清细胞因子表达(英文)

The Effect of Artificial Liver Supporting System (ALSS) on the Treatment of Severe Patients of Hepatitis B: A View from the Serum Cytokine

目的:探讨人工肝支持系统治疗重型乙肝的临床疗效。方法:将80例重型乙肝分为对照组和实验组,对照组40例,仅做一般内科治疗,实验组40例,在内科治疗基础上行人工肝支持系统治疗,每周2-3次,观察8周。采用ELISA法检测重型乙肝患者血清IL-2、TNF-α及TGF-β1水平在各组治疗后表达,数据进行统计学处理。结果:ALSS治疗后较对照组TNF-α及TGF-β1水平明显下降,而IL-2水平则呈上升趋势。结论:ALSS治疗能降低重型乙肝患者TNF-α及TGF-β1含量,并升高IL-2水平,从而抑制炎性介质的产生,减轻免疫反应对肝细胞的损伤,提高重型乙肝的存活率。

Objective： To investigate the clinic effect of artificial liver supporting system （ALSS） on the treatment of severe patients of Hepatitis B by comparing it with reference of general treatment. Methods： 80 severe patients of Hepatitis B were divided into experimental and reference groups. The patients in experimental group were treated with ALSS on the basis of internal medical treatment, while patients in the reference group only received general treatment. The observation was performed for 8 weeks with 2-3 times per week. The level of IL-2, TNF-α and TGF-β1 of the serum of patients in each group was determined by using ELISA after the treatment, and the obtained results were analyzed by using statistical methods. Results： The TNF-α and the TGF-β1 levels in the experimental group were significantly lower than those in the reference group while the IL-2 level was significantly higher than that in the reference group. Conclusion： ALSS treat can restrain the generation of inflammatory medium, which in turn mitigates the damage of immunoreactions on the liver cells and increases the livability rate of severe patients of Hepatitis B.