摘要
目的:探讨人卵巢上皮癌组织和卵巢良性肿瘤中CCN1表达水平的差异及临床意义。方法:收集我院21例卵巢上皮癌病理组织,以卵巢良性肿瘤为对照,经Real-time PCR和免疫组织化学等方法从mRNA水平和蛋白水平检测CCN1的表达水平。分析其表达水平与卵巢上皮肿瘤恶性程度的关系。结果:Real-time PCR和免疫组织化学结果均提示CCN1在卵巢上皮癌组织中的表达水平高于良性肿瘤(P<0.01)。结论:CCN1可能与卵巢上皮癌的恶性潜能密切相关。
Objective： To compare with the expression of CCNI between human epithelial ovarian cancer and ovarian benign tumor. Methods： CCN1 expression level in 21 cases ovarian cancer and 17 cases with ovarian benign by real-time PCR and immunohistochemistry staining were be quantified. We analyzed the correlation between expression level of CCNI and pathologic grade of the tumors. Results： CCN1 mRNA and protein were significantly expressed higher in epithelial ovarian cancer than in ovarian benign tumor by Real-time PCR and immunohistochemistry （P 〈 0.01 ）. Conclusion： CCN1 could play a role in progression of epithelial ovarian cancer.
出处
《现代生物医学进展》
CAS
2012年第33期6477-6479,6418,共4页
Progress in Modern Biomedicine
基金
宁夏自然科学基金(NZ09135)
宁夏医科大学面上项目(XM200842)
