抗Hp治疗对胆汁反流性胃炎合并Hp阴性者疗效的影响

Observation on the Influence of Anti-HP Treatment on the Clinical Effect of Bile Reflux Gastritis Treatment

目的:观察抗幽门螺杆菌治疗对胆汁反流性胃炎的治疗效果的影响。方法:将346例胆汁反流性胃炎合并幽门螺杆菌阴性者,分为观察组和对照组,两组均给予雷尼替丁、吗丁啉、丽珠得乐进行基础治疗,观察组加用阿莫西林、甲硝唑进行抗Hp治疗,比较两组的临床疗效。结果:观察组治愈24例(13.87%),显效55例(31.79%),有效40例(23.12%),无效54例(31.21%),总有效率为68.80%;对照组治愈11例(6.36%),显效42例(24.28%),有效45例(26.01%),无效75例(43.35%),总有效率为56.65%;两组比较差异有统计学意义(X2=10.28,P<0.05)。结论:对胆汁反流性胃炎者,即使检查示幽门螺杆菌阴性,在抗胆汁反流药物治疗的同时常规加用抗Hp治疗也可以收到较好的治疗效果。

Objective： To observe the influence of anti-helicobacter pylori treatment on the clinical effect of bile reflux gastritis treatment. Methods： 346 patients suffered from both bile reflux gastritis and helicobacter pylori negatively were divided into observation group and control groups. Both groups were given a conventional treatment using Ranitidine, Motilium and Bismuth Potassium Citrate Capsules, while the observation group was also given anti-HP treatment by using Amoxicillin and Metronidazole. The clinical effect of the two group were compared. Results： In observation group, there were 24 cases （13.87%） cured, 55 cases （31.79%） being excellent, 40 cases （23.12%） being in effect and 54 cases （31.21%） being invalid, and the total effective rate was 68.8%. While in control group, there were 11 cases （6.36%） cured, 42 cases （24.28%） being excellent, 45 cases （26.01%） being in effect and 75 cases （43.35%） being invalid, and the total effective rate was 56.65%. There were significant differences between the results of the two groups （X^2=-10.28, P〈0.05）. Conclusion： There were good clinical effects by using both anti-HP and anti-bile regurgitation drugs on patients with bile reflux gastritis and helicobacter pylori negative.