利奈唑胺治疗高龄重症肺炎致血小板减少16例临床分析

The Clinical Analysis of the Effects on Thrombocyte Caused by Linezolid in the Treatment of Severe Infection with Elderly Patients

目的:分析利奈唑胺治疗高龄重症肺炎患者致血小板减少的特点,为高龄患者合理用药提供参考。方法:回顾性分析16例高龄重症肺炎利奈唑胺治疗的临床资料,分析其临床疗效及危险因素,总结其不良反应的发生情况。结果:男14例,女2例,年龄81-99岁,平均91.2±1.4岁。有13例(81.25%)发生血小板减少,多在用药3～7天发生,停药后恢复时间5～10天。结论:利奈唑胺治疗80岁以上重症肺炎患者血小板下降发生机率高,建议应用利奈唑胺治疗过程中密切监测血象,一旦发现血小板减少,及时停药,以免严重不良反应发生。

Objective： To investigate the effects of linezolid used combine with other antibiotics on the treatment of elderly patients with severe infection. Methods： The clinical data of 16 elderly patients with severe infection who were treated with linezolid were retrospective analyzed, its clinical efficacy and risk factors was analyzed, and adverse events were summaryed. Results： Thrombocytopenia incidence was 81.25%. The time of thrombocytopenia occur was mostly 3 - 7 days after using linezolid and the platelet returned normal after 5 -7 days from stop using linezolid. Conclusion： Thrombocytopenia occur of linezolid in the treatment of over 80 years elderly patients with severe infection is highly alert, close monitoring of blood is needed in the use of linezolid in order to avoid serious adverse reactions.