雷贝拉唑三联疗法治疗胃溃疡100例临床疗效治疗

The Curative Effect of Rabeprazole Combined with Clarithromycin and Amoxicillin Capsules on 100 Innocent Gastrelcosis Patients

目的:观察雷贝拉唑联用克拉霉素、阿莫西林胶囊治疗良性溃疡疗效。方法:100例良性溃疡病人随机分成治疗组和对照组,治疗组采用雷贝拉唑+克拉霉素+阿莫西林治疗,对照组采用照组用奥美拉唑+克拉霉素+阿莫西林三联疗法,4周后复查胃镜、检测Hp并复查血、尿常规及肝肾功能。结果:治疗组有效率为94%,对照组有效率为80%,两者有显著性差异(P<0.05);治疗组Hp转阴率为88%,显著高于对照组的转阴率72%(P<0.05)。结论:雷贝拉唑三联疗法治疗胃溃疡疗效高,无明显毒副作用,值得临床推广应用。

Objective： To observe the curative effect of rabeprazole combined with clarithromycin and amoxicillin capsules on innocent gastrelcosis. Methods： A total of 100 patients with innocent gastrelcosis were randomly and equally divided into treatment group and control group. The patients in treatment group were treated with rabeprazole combined with clarithromy and amoxicillin capsules, while the patients in control group were treated with omeprazole combined with clarithromy and amoxicillin capsules. Gastroscope,H. pylori, blood, urine, liver and kidney fimction were counterchecked after 4 weeks. Results： The effective rate was about 94% in experimental group, 80% in control group; there were significant difference（P〈0.05）. The negative converting rate of experimental group was 88%, higher than that of control group （72%）（P〈0.05）. Conclusion： Rabeprazole based triple therapy have good therapeutic efficacy on Helicobacter pylori related ulcer with no conspicuous side effects, It is deserved to be widely used in curing Hp related ulcer.