香菇多糖联合地塞米松腔内注射治疗恶性胸腔积液的临床观察

The Clinical Study about Effects Lentinan (LNT) Plus Dexamethasone(DXM) Treatment for Patients with Malignant Pleural Effusions

目的观察香菇多糖(LNT)加地塞米松(DXM)腔内注射对恶性胸腔积液的治疗价值。方法将56例恶性胸腔积液患者随机分成腔内注射LNT组和腔内注射LNT+DXM组后,观察其疗效、不良反应。结果 LNT组的CR率为28.6%,PR率为46.4%,总有效率为75%;LNT+DXM组的CR率为35.7%,PR率为42.9%,总有效率为78.6%(P>0.05)。但LNT+DXM组较LNT组发热、胸痛等不良反应明显改善(P<0.05)有统计学显著差异,LNT+DXM组51.8%的患者KPS评分增高。结论 LNT组与LNT+DXM组胸腔注射均对恶性胸腔积液有良好疗效,而不良反应LNT+DXM组低于LNT组。

Objective To explore the treatment value of LNT plus DXM in patients with malignant pleural effusions. Methods 56 patients with malignant pleural effusions were random derided into group LNT（L） and group LNT ＋ DXM （L ＋ D）. They were respectively given only LNT and LNT plus DXM. To observe the efficacy and side effects. Results In group L, complete remission was 28.6% , partial remission was 46.4% and the overall response rate was 75% ;which was respectively 35.7% , 42.9% and 78.6% in group L ＋ D. But the side effects such as chest pain and fever were less in group L ＋ D than in group L. The KPS scores was higher in group L ＋ D than in group L. Conclusion LNT and LNT plus DXM were both effective methods to control malignant pleural effusions. But the side effects rate were lower in group L ＋ D than that in group L.