糖链抗原153、细胞角质素片段19和CEA联合检测评价乳腺癌的诊断价值

Diagnostic Value of Combined Detection of CA153, CY211 and CEA in Breast Cancer

目的评价糖链抗原153(CA153)、细胞角质素片段19(CY211)和CEA单项检测和联合检测用于乳腺癌的诊断价值。方法检测乳腺癌组、乳腺增生组和对照组CA153、CY211和CEA含量,并用受试者工作特征曲线(ROC)评价指标的诊断价值。结果乳腺增生组与对照组相比较,CA153含量显著升高,差异有统计学意义(P<0.05),其他二指标间无统计学意义;而乳腺癌组CA153和CY211含量显著升高,差异有统计学意义(P<0.05),CEA差异无统计学意义。乳腺癌组CA153含量与乳腺增生组相比较显著降低,而CY211和CEA含量显著升高;CA153、CY211和CEA单项检测时,CY211的诊断价值最高,诊断灵敏性和特异性分别为63.5%和68.1%;CA153、CY211和CEA联合检测时,其灵敏性和特异性分别为76.4%和74.6%。结论三项指标联检可提高检测的灵敏性和特异性,可作为临床乳腺癌的辅助诊断方法之一。

Objective To evaluate the diagnostic value of detection alone and combined detection of carbohydrate antigen 153 （ CA153 ）, cytokeratin fragment 211 （ CY211 ） and CEA in breast cancer. Methods The serum levels of CA153, CY211 and CEA were detected in the breast cancer group, mammary gland hyperplasia group and the healthy control group, respectively. The receiver operating characteristic curve was used to evaluate the diagnostic value. Results The CA153 serum levels in the mammary gland hyperplasia group were significantly higher than that of healthy control group （ P 〈 0.05 ） , but the other indicators showed no significant difference. The levels of CA153 and CY211 in breast cancer group increased significantly compared with controls （P 〈0.05 ）, and the other indicators showed hyperplasia group, the CY211 and CEA no statistically significant difference. levels were significantly increased in Compared to the mammary gland the breast cancer group, and the CA153 levels showed significantly lower. When CA153, CY211 and CEA were used alone for differentiating the breast cancer group and mammary gland hyperplasia group, CY211 had the best diagnostic value. The diagnos- tic sensitivity and specificity were 63.5 % and 68.1% , respectively. When CA153, CY211 and CEA were used for combined detection, the sensitivity and specificity were 76.4% and 74.6% separately. Conclusion The combined detection of CA153, CY211 and CEA could be used as an auxiliary diagnostic method in breast cancer