鲑鱼降钙素治疗类风湿关节炎合并骨质疏松患者的疗效观察

Clinical Observation of Treatment Bone Mineral Density and Rheumatoid Arthritis by Osteoporisis

目的探讨鲑鱼降钙素对类风湿关节炎患者合并骨质疏松症的骨密度及疼痛情况的影响。方法选择我院2009年1月至2012年2月患有类风湿关节炎合并骨质疏松的66例患者,随机分为治疗组(32例)和对照组(34例),两组均进行补钙和抗风湿的基础治疗,治疗组上述治疗基础上加用鲑鱼降钙素。比较两组患者治疗前、后骨密度及NRS疼痛评分的变化。结果治疗3个月后显示,治疗组患者治疗后腰椎和股骨近端密度均有显著增加且比对照组高,而疼痛评分在治疗后治疗组明显低于对照组,治疗后两组骨密度及疼痛评分差异均有统计学意义(P<0.05)。结论常规剂量的鲑鱼降钙素配合补钙、抗风湿治疗能增加类风湿关节炎合并骨质疏松症患者的骨密度,明显改善患者疼痛情况。

Objective To explore the influence of bone mineral density（BMD） and pain situation of Salcatonin on the treatment of rheumatoid arthritis（RA） with osteoporisis. Methods Sixty-six patients treated by our hospital between Jan.2010 and Feb.2012 eligible for this study were included. All the patients are distributed randomly into two group, treatment group（32 patients） and control group（34 patients）.Two groups are treated with anti-rheumatoid and calcium supplement medicine. Based on that treatment, conventional dose of Salcatonin are given on treatment group. The bone mineral density and NRS pain score of two group are compared between prior treatment and post treatment. Results The BMD in the lumbar spine and the proximal femur were significant altered in patients of treatment group after 3 month treatment,higher than control group. The NRS pain score in treatment group is lower than control group after 3 months＇ treatment. Statistic significant difference between the two groups in BMD and NRS pain score was detected（P0.05）.Conclusions conventional dose of Salcatonin combined with anti-rheumatoid and calcium supplement medicine can increase BMD of RA patients with osteoporisis, and relieve their pain.