脑肿瘤治疗前后血清和脑脊液唾液酸含量变化分析

Sialic Acid Content of Serum and Cerebrospinal Fluid in the Brain Tumor before and after Treatment Analysis

目的探讨分析脑肿瘤患者在脑肿瘤治疗前后血清唾液酸(SA)和脑脊液(CSF)唾液酸(SA)含量的变化,来作为治疗后临床疗效的观察指标。方法选择于2008年5月—2010年3月在该市第一人民医院接受治疗的90例患者作为研究对象,其中50例为脑肿瘤患者(设为观察组),另外40例患者患有鞘膜积液和股骨沟疝(设为对照组),通过SA比色测定的方法来检测这些脑肿瘤患者在脑肿瘤治疗前后血清SA和CSF-SA含量的变化和测定对照组患者的血清SA和CSF-SA含量。结果经过一段的治疗后脑肿瘤患者的血清SA和CSF-SA都出现了一定程度的改变,血清SA的含量增多,而CSF-SA的含量却减少,且良性肿瘤患者减少含量更为显著,与恶性肿瘤患者比较,差异有统计学意义(P<0.05),观察组与对照组患者比较,差异有统计学意义(P<0.01)。结论通过检测观察脑肿瘤患者在脑肿瘤治疗前后血清SA和CSF-SA含量的变化可以评估治疗效果,判断是否出现复发情况,且从CSF-SA变化中能够更直接、迅速地作出评估和判断。

Objective To investigate the change of serum sialic acid and cerebrospinal fluid sialic acid in the brain tumor patients before and after the treatment. Methods We chose 90 patients in the No.1 People＇s Hospital in our city from May, 2008 to March, 2010 and divided them into two groups, the observation group with 50 brain tumor patients, the control group with 40 hydrocele and ditch femoral hernia patients. We measured the change of serum SA and CSF-SA in the patients before and after the treat- ment and the specific content of serum SA and CSF-SA in the control group with the method of SA color contrast. Results After a period of treatment, serum SA and CSF-SA both changed in the two groups. The serum SA content increased, while the content of CSF-SA was decreased, and the patients with benign tumors was more obvious in CSF-SA decreasing.The comparison with malig- nant tumor patients had statistical significance （P〈0.05） and the comparison between the observation group and the control group was also of statistical significance（P〈0.01）. Conclusion Through the change of serum SA and CSF-SA contents in the patients be- fore and after the treatment, we can value the treatment effect, judge the possibility of complications and make direct and quick judgment from the change of CSF-SA.