布氏杆菌病229例临床分析

Clinical analysis of 229 cases of brucellosis

目的:探讨布氏杆菌病的临床表现及实验室检查变化的特点,总结布氏杆菌病诊断及治疗的经验。方法:经ELISA方法确诊的229例布氏杆菌病患者,为哈尔滨医科大学附属第一医院2005年1月至2011年6月期间的住院患者,对他们的流行病学资料、临床表现及实验室检查的变化进行回顾性分析,并总结这些变化的特点。结果:与以往相比,农村发生布氏杆菌病的比例升高,不明原因传播途径的比例升高,不规则发热的比例升高,临床表现多样化,规范地联合用药治疗痊愈较快、预后较好。结论:布氏杆菌病的临床特点在不断发生变化,临床医师应加强对本病的认识,减少误诊率,并坚持进行规范的抗菌治疗。

Objective： To review the clinical manifestation and laboratory examination of brucellosis.Methods： The clinical data of 229 patients with brucellosis admitted from January 2005 to June 2011 were retrospectively analyzed.Results： Compared with the past,the prevalence proportion in rural area,uncertain infectious route and irregular fever type of brucellosis increased.The clinical manifestation became diverse,and standard combination therapy made patients recover more quickly,and get a better prognosis.Conclusions： Compared with the past,the clinical manifestation of brucellosis has changed partly.In order to avoid misdiagnosis and mistreating,clinical doctors should study the new characteristics of brucellosis and persist in taking the standard antibiotic treatment.