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肝脏疾病转化医学研究进展 被引量:1

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摘要 在医药领域,大家意识到每年都有成千上万项所谓创新型的研究以论文的形式发表,然而,真正能成为临床诊断、治疗的新技术和新方法却寥寥无几,而这才是我们必须面对和反思的问题。自2003年美国Zerhouni在NIH路线图计划(NIHRoadmap)中提出转化医学概念后,转化医学已成为目前全球医药界最为热门的词汇。这种双向转化的研究模式突破了传统模式中实验室基础研究和临床研究、医学实践各自为政的缺陷,强调以患者需求为导向,促使研究成果尽快实现临床转化,在基础和临床之间架构起真正的桥梁。
作者 茅益民
出处 《肝脏》 2012年第11期761-765,共5页 Chinese Hepatology
基金 "十二五"科技重大专项"肝脏疾病临床研究和转化医学技术平台的构筑"(2012ZX09303-001) "十二五"科技重大专项"辽宁药联创新药物孵化基地建设"(2012ZX09401004) 上海市科委课题"非酒精性脂肪性肝病标准化资源库构建及综合预警体系筛查研究"(10411956200) 上海市科委课题"熊去氧胆酸片治疗脂肪肝的临床研究"(09DZ1905900) 985工程三期子项目"药物性肝损伤标准化资源库平台构建及生物标记筛查的研究" 上海市教委"上海高校一流学科"建设B类 中国肝炎防治基金会王宝恩肝纤维化研究基金"非酒精性脂肪性肝病中颈动脉内中膜(IMT)增厚的危险因素分析及其与肝纤维化关系的研究"
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同被引文献17

  • 1Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther, 2011,34: 274-285.
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  • 3Everhart JE, Bambha KM. Patty liver: think globally. Hepatology, 2010,51: 1491-1493.
  • 4Pabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology, 2010,51: 679-689.
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  • 8Younossi ZM, Stepanova M, Rafiq N, et aL Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology, 2011, 53: 1874-1882.
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