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Dickkopf-1在强直性脊柱炎病理过程中作用研究进展 被引量：3

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摘要 Dickkopf-1(Dkk-1)是Wnt信号路径的天然抑制因子,通过抑制Wnt信号传导通路影响骨化活动。体内Dkk-1血清水平降低、与Dkk-1受体的黏附功能下降或Dkk-1功能受损均可降低Dkk-1对Wnt信号传导通路的抑制作用,促进细胞内β-连环蛋白水平升高并活化,从而调节成骨细胞分化和倾向于骨生成,最终使强直性脊柱炎患者形成关节强直。强直性脊柱炎的炎症本身不受Dkk-1影响,且可以诱导Dkk-1的表达。
作者 雷鹏真 危国军 裴孝鹏 康凯 董大明
机构地区 哈尔滨医科大学附属第二医院骨三科
出处 《中华实用诊断与治疗杂志》 2012年第12期1149-1151,共3页 Journal of Chinese Practical Diagnosis and Therapy
基金 黑龙江省自然科学基金(D201183)
关键词 强直性脊柱炎 WNT信号传导通路 DKK-1 骨生成
分类号 R593.23 [医药卫生—内科学]
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参考文献19

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二级参考文献7

共引文献9

同被引文献50

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引证文献3

二级引证文献17

中华实用诊断与治疗杂志
2012年 第12期

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