类风湿性关节炎患者血清及关节积液SOCS-1、SOCS-3蛋白的含量检测及意义

The content and value of SOCS-1 and SOCS-3 proteins in serum and synovial fluid of patients with rheumatoid arthritis

目的观察类风湿性关节炎(RA)患者血清及关节液SOCS-1、SOCS-3蛋白含量的变化,探讨其在炎症中的意义。方法 49例类风湿性关节炎患者根据疾病活动性分为活动期组(26例)及缓解期组(23例),采用ELISA法检测其血清及关节液SOCS-1、SOCS-3蛋白含量,并与20例健康体检者(对照组)进行比较。结果与对照组比较,RA患者中活动期组与缓解期组血清SOCS-1、SOCS-3蛋白含量均明显升高(P<0.01),其中活动期组血清SOCS-1、SOCS-3含量表达较缓解组明显升高(P<0.01、P<0.05);活动期组患者关节积液SOCS-1、SOCS-3蛋白表达较缓解期组明显升高(P<0.05);活动期组患者血清SOCS-1、SOCS-3蛋白水平均与血清ESR、CRP、RF呈正相关(P<0.01、P<0.05)。结论 SOCS 1/3可能参与了RA炎症反应的病理过程,且可能与RA病情活动性有关。

Objective To investigate the changes of the levels of serum and synovial fluid SOCS-1 ,SOCS-3 in pa- tients with rheumatoid arthritis（RA）, and to explore the value of SOCS-1 and SOCS-3 in inflammatory reaction of rheumatoid arthritis. Methods 49 patients with rheumatoid arthritis were divided into active RA group （26 cases） and non- active RA group（23 cases）according to disease activity index. The levels of serum and synovial fluid SOCS- 1, SOCS-3 were detected by ELISA, while the 20 healthy control were compiled into the control group. Results The levels of serum SOCS-1 and SOCS-3 were significantly higher in RA group than those in control group（ P 〈 0. 01 ）, which were significantly higher in active RA group than those in non- active RA group （ P 〈 0. 01, P 〈 0. 05 ）. The levels of synovial fluid SOCS-1 and SOCS-3 were significantly higher in active RA group than those in non- active RA group（ P 〈 0. 05）. The levels of serum SOCS-1 and SOCS-3 were positively correlated with the serum ESR, CRP, RF （P 〈 0. 01,P 〈 0.05 ）. Conclusions SOCS-1 and SOCS-3 may play an important role in the pathological process of inflammatory response in rheumatoid arthritis, which may be related to activity of rheumatoid arthritis.