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糖尿病肾病患者脂联素水平和颈动脉粥样硬化的关系 被引量：4

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摘要 脂联素是新近发现的脂肪细胞特异性蛋白，研究显示脂联素可以通过抑制内皮细胞黏附分子的表达、平滑肌的增殖以及巨噬细胞向泡沫细胞的转变，终止炎症反应、改善脂代谢等几个方面阻止动脉粥样硬化形成。且多项研究证实脂联素水平下降是2型糖尿病发病的独立危险因素。
作者 徐丰博 刘惠兰 孙懿
机构地区 首都医科大学附属复兴医院肾内科
出处 《中华内科杂志》 CAS CSCD 北大核心 2012年第12期996-997,共2页 Chinese Journal of Internal Medicine
关键词 颈动脉粥样硬化 糖尿病肾病患者 脂联素 内皮细胞黏附分子 动脉粥样硬化形成 独立危险因素 水 特异性蛋白
分类号 R587.2 [医药卫生—内分泌] R692.9 [医药卫生—泌尿科学]
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参考文献6

  • 1Kato K, Osawa H, Ochi M, et al. Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy. Clin Endocrinol (Oxf) , 2008 , 68 : 442449.
  • 2Lenghel AR, Kacso 1M, Bondor CI, et al. Intercellular adhesion molecule, plasma adiponectin and albuminuria in type 2 diabetic patients. Diabetes Res Clin Pract,2012 ,95 :55-61.
  • 3Looker HC, KrakoffJ , Funahashi T, et al. Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes.J Clin Endocrinol Metab,2004,89:40104017.
  • 4Saito T, Saito 0, Kawano T, et al. Elevation of serum adiponectin and CD146 levels in diabetic nephropathy. Diabetes Res Clin Pract, 2007 ,78 : 85 -92.
  • 5Barlovic DP, ZaletelJ , PrezelJ J , et al. Adipocytokines are associated with renal function in patients with normal range glomerular filtration rate and type 2 diabetes. Cytokine, 2009,46: 142-145.
  • 6FuJ ita H, Morii T, KoshimuraJ , et al. Possible relationship between adiponectin and renal tubular inJ ury in diabetic nephropathy. EndocrJ , 2006,53:745-752.

同被引文献56

  • 1关悦,乔虹.同型半胱氨酸与糖尿病肾病的相关性研究[J].医学研究生学报,2011,24(5):547-549. 被引量：14
  • 2Cui R,Iso H,Yamagishi K,et al.Diabetes mellitus and risk of stroke and its subtypes among Japanese:the Japan public health center study[J].Stroke,2011,42(9):2611-2614.
  • 3Bahia LR,Araujo DV,Schaan BD,et al.The costs of type 2 diabetes mellitus outpatient care in the Brazilian public health system[J].Value Health,2011,14(5 Suppl 1):S137-S140.
  • 4Zhuo L,Zou G,Li W,et al.Prevalence of diabetic nephropathy complicating non-diabetic renal disease among Chinese patients with type 2 diabetes mellitus[J].Eur J Med Res,2013,22(18):4.
  • 5Xia J,Zhong Y,Huang G,et al.The relationship between insulin resistance and osteoporosis in elderly male type 2 diabetes mellitus and diabetic nephropathy[J].Ann Endocrinol(Paris),2012,73(6):546-551.
  • 6Lajer M,Tarnow L,Jorsal A,et al.Plasma concentration of asymmetric dimethylarginine(ADMA)predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy[J].Diabetes Care,2008,31(4):747-752.
  • 7Bentata Y,Haddiya I,Latrech H,et al.Progression of diabetic nephropathy,risk of end-stage renal disease and mortality in patients with type-1 diabetes[J].Saudi J Kidney Dis Transpl,2013,24(2):392-402.
  • 8Guo LL,Pan Y,Jin HM.Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensinⅡtype 1 receptor blocker losartan[J].Nephrol Dial Transplant,2009,24(6):1876-1883.
  • 9Ran J,Xiong X,Liu W,et al.Increased plasma adiponectin closely associates with vascular endothelial dysfunction in type 2 diabetic patients with diabetic nephropathy[J].Diabetes Res Clin Pract,2010,88(2):177-183.
  • 10Utsumi K,Yasuda F,Watanabe Y,et al.Effects of olmesartan and imidapril on the plasma adiponectin,P-selectin,and MDA-LDL levels of diabetic nephropathy patients[J].Clin Chim Acta,2012,413(1/2):348-349.

引证文献4

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中华内科杂志
2012年 第12期

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