影响胃癌根治术预后相关因素分析

The analysis of prognostic factors for gastric cancer after radical resection

目的探讨影响胃癌根治术预后的相关因素。方法选取该院收治的进展期胃癌患者138例,行胃癌根治术治疗,将患者性别、年龄、肿瘤大小、Bommann分型、组织学分型、TMN分期等资料纳入研究,探讨影响胃癌根治术预后因素。结果所有患者术后均获得随访,术后1年生存率为84.1%(116/138),术后3年生存率为51.4%(71/138)。单因素分析显示,肿瘤大小、Bommann分型、组织学分型、TMN分期、淋巴结清扫、血管侵犯、辅助化疗等因素为影响患者预后的相关因素,差异有统计学意义(P<0.05)。COX回归分析发现,组织学分型、TNM分期、血管侵犯及肿瘤大小为影响胃癌根治术患者预后的独立危险因素,差异有统计学意义(P<0.05)。结论组织学分型、TNM分期、血管侵犯及肿瘤大小对胃癌根治术患者的预后均有较大的影响,建立早期的肿瘤筛查模式为提高患者预后显得尤为重要。

Objective To analysis the prognostic factors for gastric cancer after radical resection.Methods A total of 138 advanced gastric cancer patients were selected in our hospital with radical resection,patients gender,age,tumor size,Bommann classification,histological type,TMN stage and other material included in this study,to investigate the risk factors of prognosis on advanced gastric cancer.Results All of the patients with followed-up,after one year surgery the survival rate was 84.1%（116/138）,after 3 years of survival rate was 51.4%（71/138）.Single factor analysis shows,tumor size,Bommann classification,histological type,TMN stage,lymph node dissection,vascular invasion,adjuvant chemotherapy were the risk factors of prognosis on advanced gastric cancer,P0.05.COX regression analysis shows that histological type,TMN stage,vascular invasion and tumor size were the independent risk factors of prognosis on advanced gastric cancer,P0.05.Conclusion Histological type,TMN stage,vascular invasion and tumor size has great influence of prognosis on advanced gastric cancer,to establishment of the early cancer screening mode to improve the prognosis is particularly important.