宫内感染乙型肝炎病毒对胎儿生长发育的影响

The Influencing factor and correlation analysis of intrauterine HBV infection for foetus growth

目的探讨和研究宫内感染乙型肝炎病毒(HBV)对胎儿生长发育的影响。方法选取安徽省淮南市第一人民医院近年来收治的37例乙型肝炎病毒表面抗原(HBsAg)阳性的孕妇及其新生儿作为观察组,并随机选取同期的37例健康孕妇及其新生儿作为健康对照组,对两组孕妇的妊娠并发症、围生儿结局以及胎儿生长发育的情况进行对比分析。结果观察组孕妇所生的新生儿出生体质量和胎盘体积较健康对照组小,而孕妇HBV感染情况与新生儿体质量、身长以及胎儿生长受限(FGR)情况并无明显关系;新生儿中HBsAg阳性者体质量、身长及胎盘体积均较阴性者低,FGR发生率高;新生儿乙型肝炎病毒e抗原(HBeAg)阳性组FGR发生率较高;新生儿乙型肝炎病毒表面抗体(抗-HBs)阳性组胎盘体积较大。结论宫内感染HBV有可能导致胎盘体积缩小,新生儿出生体质量降低,而新生儿抗-HBs阳性对胎盘具有一定的保护作用。

Objective To explore and research influencing factor and correlation of intrauterine HBV infection for foetus growth. Methods 37 cases of hepatitis B surface antigen masculine gender pregnant women and newborn babies were the observational group, 37 cases of normal pregnant women and newborn babies were randomly selected to be the control group. The pregnancy complications, perinatal outcome and foetus growth of two groups were analysed. Results The birth weight and placental volume of babies in observational group were less than the control group,there was no apparent relationship between intrauterine HBV infection and the birthweight, height, fetal growth restriction（FGR）. The birth weight, height and placental volume of hepatitis B surface antigen masculine gender patients were lower than the negative person. The fetal growth restriction of the observational group was higher than the control group. Conclusion Intrauterine HBV infection reduces the placental volume and the birth weight, but hepatitis B surface antigen masculine gender newborn babies has the protection to placenta.