慢性阻塞性肺疾病患者治疗前后血清相关指标检测的临床意义

Clinical Significance of determinations of Serum NO,NOS,IL-10,IL-18 and GM-CSF levels after treatment in patients with chronic obstructive pulmonary diseases

目的探讨了慢性阻塞性肺疾病(COPD)患者治疗前后血清一氧化氮(NO)、一氧化氢合成酶(NOS)、白细胞介素-10(IL-10)、白细胞介素-18(IL-18)和粒细胞巨噬细胞集落刺激因子(GM-CSF)水平的变化及临床意义。方法分别采用放免法和化学法对38例COPD患者进行了治疗前后血清NO、NOS、IL-10、IL-18和GM-CSF水平检测,并与35例健康人作比较。结果 COPD患者在治疗前血清NO、NOS、IL-10、IL-18和GM-CSF水平均非常显著地高于健康对照组(P<0.01),经综合治疗后2周,除NO水平与健康对照组比较无差异外,NOS、IL-10、IL-18和GM-CSF水平与健康人比较差异有统计学意义(P<0.05)。结论 NO、NOS、IL-10、IL-18和GM-CSF可能以不同的方式参与了COPD的发病,其水平的检测对了解病情,指导治疗均具有重要的临床价值。

Objective To explore the significance of changes of Serum NO,NOS,IL-10,IL-18 and GM-CSF levels after treatment in patients with chronic obstructive pulmonary diseases. Methods Serum IL-10, IL-18, GMCSF levels were determined by RIA and Serum NO, NOS levels were determined by chemical methods both before and after treatment in 38 patients with COPD as well as in 35 controls. Results Before treatment the Serum NO, NOS,IL-10,IL-18 and GM-CSF levels were significantly higher than those in controls （P〈0.01）. After 2 weeks of treatment, the NO, NOS, IL-10,IL-18 and GM-CSF levels were significantly higher than those in controls（P〈0.05） except NO level. Conclusion NO, NOS, IL-10, IL-18 and GM-CSF could take part in the pathogenesis of COPD in various ways and determinations of these levels are clinically important.