抑郁症住院患者静息态的脑磁频谱分析

A magnetoencephalography analysis of resting state power spectrum of inpatients with major depressive disorder

目的探讨抑郁症患者与正常对照静息态脑磁频谱分布特征的差异。方法12例女性抑郁症患者（患者组）和12名年龄、受教育程度相匹配的女性健康对照者（对照组）接受脑磁图静息态扫描，通过频谱分析计算delta、theta、alpha、beta各频段在感兴趣皮质区的能量并作归一化处理，应用MATLAB7．8进行双样本t检验获得组间差异。结果与对照组比较，患者组的有顶（患者组：0．031，对照组：0．017；t=1．911，P=0．035）alpha频段能量增强，左顶（患者组：0．025，对照组：0．015；t=2．504，P=0．010）、右顶（患者组：0．026，对照组：0．016；t=2．063，P=0．026）、左枕（患者组：0．054，对照组：0．029；t=3．000，尸=0．003）、有枕（患者组：O．046，对照组：O．032；t=2．035，P=0．027）beta频段能量增强，左枕（患者组：0．029，对照组：0．049；t=－1．788，P=0．044）delta频段能量减弱，右中央（患者组：0．005，对照组：0．012；t=－1．820，P=0．041）、有颞（患者组：0．015，对照组：0．023；t=－1．934，P=0．033）theta频段能量减弱。结论抑郁症患者与对照组相比在快波（beta）、慢波（delta，theta）、alpha频段脑磁能量值均存在差异，且主要位于大脑半球后半部。

Objective To explore the discrepancies of magnetoencephalography （MEG） spectral power between female patients with major depressive disorder and nondepressed subjects in resting state. Methods Whole head MEG recordings were obtained in 12 female patients with major depressive disorder and 12 age- and education- matched nondepressed control subjects in resting state condition with eyes closed. Each region＇s mean power in delta, theta, alpha, beta frequency bands was calculated through power normalization. Discrepancies between groups were obtained by two sample t-test using MATLAB 7. 8. Results The power of alpha and beta fi＇equency bands in patients was increased relative to controls, the abnormal brain regions were separately shown as follows （0.031 vs. 0.017;t = 1.911, P =0.035）,the beta the alpha frequency band in the right parietal lobe frequency band in the left parietal lobe （O. 025 vs. 0. 015;t =2. 504, P =0. 010） ,the right parietal lobe（0. 026 vs. 0. 016;t =2. 063, P =0. 026）, the left occipital lobe（0. 054 vs. 0. 029;t = 3. 000, P = 0. 003 ） and the right occipital lobe （0. 046 vs. 0. 032;t = 2. 035, P = 0. 027）. The power of delta and theta frequency bands was decreased in patients relative to controls, the abnormal brain regions were separately shown as follows： the delta frequency band in the left occipital lobe （0. 029 vs. 0. 049 ; t = - 1. 788, P = 0. 044） ; the theta frequency band in the right central region（0.005 vs. 0.012;t = - 1.820, P =0.041） and the right temporal lobe（0.015 vs. 0.023;t = - 1. 934, P =0. 033）. Conclusions The discrepancies of spectral power show a prevalence in posterior brain areas involving delta, theta, alpha and beta frequency bands in depressed patients in comparison with nondepressed comparison subjects.