经前综合征的诊治探讨

Pharmaceutic treatment of premenstrual syndrome

目的 探讨一般疗法和溴隐亭治疗经前综合征(PMS)的疗效及治疗机理。方法 PMS患者 80例 ,随机分成 2组 ,分别予一般疗法和溴隐亭治疗 ,并于治疗前后抽血测血PRL浓度。结果 两组患者血清PRL浓度均较正常值 (2 3miu/ml)升高 ,溴隐亭治疗组治疗后PRL浓度明显降低 (P <0 .0 1) ,经前症状随之改善 ,且溴隐亭治疗组疗效明显好于一般治疗组 (P <0 .0 1)。结论 PMS的发病与PRL升高有一定关系 ,溴隐亭治疗PMS疗效肯定 ,它是通过降低血中PRL浓度来起作用的。

Objective\ To explore pharmaceutic therapy on premenstrual syndrome (PMS).Methods\ Eighty patients with premenstrual syndrome were randomly divided into two groups.One group was treated by ordinary drugs and another by Bromocriptine.PRL concentrations in plasma were measured both before and after treatment.Results\ Pre-treatment PRL concentrations in all patients with PMS were higher than normal value (23miu/ml).After having been treated by Bromocriptine,the PRL concentration was significantly lower than that of pre-treatment(P<0.01)and the premenstrual symptoms were improved.In the group treated by ordinary drugs,the changes in PRL concentration were not significant.The effect of Bromocriptine was significantly better than that of ordinary treatment (P<0.01).Conclusion\ There is certain relationship between PRL and PMS.Bromocriptine is a useful drug for treating PMS.