弓形虫感染对中枢神经影响的研究进展

Advances in the study of the effects of Toxoplasma gondii infection on the central nervous system

刚地弓形虫是我国重要的食源性寄生虫之一,对人类身体健康造成严重危害。孕期感染造成胎儿发育异常、流产、死胎等不良孕产结果,先天感染是婴幼儿发育迟缓、智力障碍的重要因素,弓形虫感染还与成年人一系列神经精神症状(特别是精神分裂症)密切相关,可能与弓形虫偏向损害中枢神经系统的现象有关。复杂的生活史造成临床症状的多样性,给明确诊断和正确治疗带来巨大困扰。本文综述弓形虫感染对中枢神经系统的影响。

Toxoplasmosis is a significant foodborne parasitic disease in China and a serious health hazard to human beings.Infection during pregnancy may cause fetal abnormalities,abortion,or stillbirth.Congenital infection is a major factor for developmental delays and intellectual impairment.Toxoplasma gondii infection is closely associated with a series of psychiatric symptoms（particularly schizophrenia） in adults possibly as a result of damage to the central nervous system by T.gondii.The complex life cycle of T.gondii causes various clinical symptoms,greatly hampering its correct diagnosis and treatment.This paper discusses the effects of T.gondii infection on the central nervous system.