血浆同型半胱氨酸水平与脑梗死关系研究

Study on the relevance between plasma homocysteine levels and cerebral infarction

目的探讨急性脑梗死与血浆同型半胱氨酸(Hcy)的关系。方法 2012-01—2012-04诊治的急性脑梗死患者50例为观察组,选取同期进行健康体检病例50例为对照组,进行血浆同型半胱氨酸检测并比较。根据入院24h内血浆同型半胱氨酸水平是否升高,采用美国国立卫生研究院卒中量表(NIHSS)对2组患者入院时、发病后4周神经功能缺损评分对比。结果血同型半胱氨酸观察组(17.60±8.98)μmol/L,对照组(10.71±4.49)μmol/L,差异有统计学意义(P<0.05);急性梗死患者发病后4周神经功能缺损对比,观察组(9.95±3.63),对照组(7.92±2.82),差异有统计学意义(P<0.05)。结论高同型半胱胺酸血症与急性脑梗死发生发展有密切关系,对急性脑梗患者预后产生不良影响,控制高同型半胱胺酸血症对有效改善脑卒中患者的预后有着重要的指导意义。

Objective To observe the relevance between plasma homocystein （Hey） level and ischemia cerebral stroke （ICS）. Methods Totally 50 patients with cerebral infarction were selected as the observation group, who were treated in our hospital from January 2011 to April 2011. We chose 50 patients with normal physical examination as control group. Plasma bo mocysteine levels were detected and compared between the two groups. The neurological impairment was evaluated by National Institutes of Health Stroke Scale （NIHSS）. Results The patients＇plasma concentration of homocysteine was （17.60±8.98） μmol/L in observation group, which was （10.71±4.49） μmol/L in control group. The difference was statistically significant （P〈0.05） between the two groups. The score of neurologic impairment was 9.95±3.63 in observation group after 4 weeks of onset, compared with control group, which was 7.92± 2.82, there was a statistical difference（P〈0.05）. Conclusion Plasma Hey concentration in the ICS patients is related to ICS. High level of plasma homocystein is an independent risk factor for ICS.