摘要
提高人类同种异体肾脏移植术后的长期存活率。方法 :收集我院自 1977年 10月至 1996年 5月肾脏移植的临床资料 ,以及手术切除的无功能移植肾病理标本 ,共 85例作为实验组 ;收集其相应的肾脏移植术前活检组织作为对照组。从临床病理学的角度 ,比较临床上不同的免疫抑制剂治疗组间的细胞凋亡程度 ,分析与免疫抑制剂治疗对移植肾细胞凋亡的影响。结果 :环孢霉素A(CsA) +泼尼松 (Pred) +硫唑嘌呤 (AZa)三联用药组和CsA +Pred +雷公藤多甙 (GTW )三联用药组相互与Pred +Aza二联用药组比较 ,前两组移植肾细胞凋亡程度明显轻于Pred +AZa二联用药组 (P <0 0 5 )。结论 :三联用药的免疫抑制剂治疗能减少移植肾细胞凋亡。
Objective:In order to improve the long term survival of renal allografts, a study of effects of immunosuppressants on apoptosis of renal was designed in this series. Methods:Eighty five cases of failed renal allografts were investigated histopathologically. 85 specimens from pretransplant biopsy were simultaneously observed as a control group. Results: Apoptosis phenomenon in all cases was found with morphologically characterized nuclear breakdown. The degree of apoptosis in triple therapy group was significantly slighter than that in double therapy group ( P <0 05). Conclusion:Triple therapy can protect tubular epithelium from apoptosis more effectively than double therapy.
出处
《军医进修学院学报》
CAS
2000年第2期120-122,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
肾移植
细胞凋亡
免疫抑制剂
renal allografts
apoptosis
immunosuppressant
