基层儿童医院门急诊123例药品不良反应分析

Analysis of 123 out - patient pediatric cases with adverse drug reaction in Chenzhou children' s hospital

目的分析基层儿童医院门急诊药品不良反应发生的相关因素,为合理用药提供依据。方法采用回顾性分析,利用Excel建立数据库,对郴州市第一人民医院儿童医院门急诊2011年1～9月上报的药品不良反应报告123例进行分析,并对其性别、年龄、给药途径、涉及品种及临床主要表现进行分类统计和分析评价。结果 123例ADR报告涉及药品7大类38种,导致ADR依次是头孢类、青霉素类和抗病毒类;静脉滴注导致ADR例数占大多数(98%);严重ADR20例(15%)。结论临床应重视儿童抗菌药物使用的安全性,严密关注严重ADR药品,尽量减少采用静脉滴注给药方式,加强ADR报告工作。

Objective To analysis the related factors of adverse drug reaction （ADR） case in Chenzhou children＇s hospital. Methods 123 cases with ADR were collected by pharmaciest from Jan. 2011 to Sep.2011 were analyzed statistically in respects of age, gender, route of administration , drug types and main clinical manifestations. Results Among 123 children＇s ADR cases, There were 7 category involved 38 kinds of drugs. Most of ADR cases were induced by cephalosporins in 59 （48% ）. Intravenous dripping was major route of administration in 127 cases （98 % ）. There were 20 severe ADR cases. Conclusion We should pay attention to the safety of antiotics use in children＇s patients and strengthen ADR reporting and monitoring.