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蚓激酶引起职业性哮喘:附2例病例报道 被引量:2

Occupational Asthma Induced by Inhaling Lumbrokinase Aerosol:A Two-case Report
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摘要 目的探讨皮肤点刺试验、结膜和(或)支气管激发试验,在蚓激酶这类罕见的职业环境中引起的职业性哮喘的诊断意义。方法对2例怀疑职业环境中接触蚓激酶粉尘引起的哮喘患者进行临床表现总结,并用蚓激酶粉剂稀释液(10μgml)分别对2例患者和3例健康对照进行皮肤点刺试验;对例1进行支气管激发试验;对例2进行结膜激发试验。结果 2例患者蚓激酶皮肤点刺试验均为阳性,3例健康对照者均为阴性。例1支气管激发试验阳性,FEV1.0从103%预计值降到83%预计值。例2左侧眼结膜激发试验阳性,作为对照的右侧眼结膜为阴性。结论蚓激酶作为一种药用蛋白质,其粉尘可以引起职业性哮喘,特异性皮肤点刺试验、结膜和(或)支气管激发试验有助于诊断。 Objective and/or bronchial To investigate the provocation test ( importance of skin prick test ( SPT), conjunctiva provocation test(CPT) BPT) in the diagnosis of occupational asthma induced by rare allergen such as lumbrokinase. Methods Medical history was collected carefully in two cases of suspected lumbrokinase induced occupational asthma patients. SPT were lumbrokinase ( 10 μg/ml) in these two patients and three healthy was also performed respectively. Results SPT of lumbrokinase in three healthy controls. The BPT was positive in patients A predicted. The CPT was positive in patient B' s left eye Conclusions Inhalation of lumbrokinase aerosol could induce perfo^naed by using the saline solution of controls. BPT and CPT in patient A and B was positive in both patients, and negative with FEV1. 0 reduced while negative in ri occupational allergic from 103% to 83% ght eye as control. rhinitis and asthma, of which culprit is a protein. SPT and CPT and/or BPT might be helpful tools for the diagnosis
出处 《中华临床免疫和变态反应杂志》 2012年第4期304-307,F0003,共5页 Chinese Journal of Allergy & Clinical Immunology
关键词 职业性哮喘 蚓激酶 皮肤点刺试验 特异性结膜激发试验 特异性支气管激发试验 occupational asthma lumbrokinase skin prick test specific conjunctiva provocation test specific bronchial provocation test
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