妊娠期脂质过氧化作用与围产儿预后的关系

Investigation of relationship between lipid peroxidation of intrahepatic cholestasis during pregnancy and the prognosis of fetus and neonates

目的 探讨脂质过氧化(LPO)作用与围产儿预后的关系。方法 选择正常晚期妊娠妇女102例和妊娠期肝内胆汁瘀积症(ICP)患者126例。分别测定LPO和红细胞超氧化物歧化酶(RBC-SOD)活性;比较新生儿出生体重、Apgar评分和羊水状况。结果 ICP组母血LPO和RBC-SOD均明显高于对照组,二者呈显著正相关。在ICP组,宫内生长受限(IUGR)、新生儿窒息和羊水异常时,脐血LPO浓度均明显增高,而脐血RBC-SOD活性均明显下降。脐血LPO与新生儿出生体重和Apagr评分呈明显负相关。结论 LPO与ICP围产儿不良预后密切相关。

Objective To investigate the relationship of Lipid Peroxidation (LPO) and perinatal prognosis of intrahepatic cholestasis during pregnancy (ICP). Methods Activity of LPO and Red Blood Cell Super-Oxide Dismutase (RBC-SOD) of 126 ICP women and 102 non-ICP control women were examined separately, and the birth weight. Apgar score and amniotic fluid status of newborns were compared between the two groups. Results LPO and RBC-SOD, with significantly positive association, of ICP mothers were significantly higher than those of control mothers. In ICP group, those with intra-utera growth retardation (IUGR), neonatal asphyxia and amniotic fluid abnormality have remarkably increased LPO concentration and deceased cord blood RBC-SOD . It shows significantly negative association between neonatal birth weight, Apgar score and cord blood LPO concentration. Conclusion LPO is tightly related to perinatal prognosis of ICP.