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绿茶成分EGCG抗肿瘤作用研究进展 被引量：3

Advances in research on Anticancer effect of (-)-Epigallocatechin Gallate (EGCG)
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摘要 表没食子儿茶素没食子酸酯(EGCG)是绿茶的主要活性成分。近年来越来越多的科学工作者将注意力集中在儿茶素单体EGCG的抗肿瘤作用上,证实了EGCG具有广泛的生物学特性和药理效应,能够抑制多种肿瘤的形成和发生,是茶叶中抗肿瘤效应的主要活性成分,本文就近年来国内外EGCG抗肿瘤作用机制研究进行综述。 （-）-Epigallocatechin gallate （EGCG） is the main active ingredient in green tea.The anticancer mechanism of EGCG has gained significant attention among scientists in recent years and has been proved to possess a wide range of biological and pharmacological properties, which can inhibit the formation and development of multiple cancers. This paper reviews some of the reported anticancer mechanisms of EGCG.
作者 滕翠琴 龚受基 刘仲华
机构地区 湖南农业大学园艺园林学院、茶学教育部重点实验室
出处 《茶叶通讯》 2012年第4期8-13,共6页 Journal of Tea Communication
关键词 EGCG 肿瘤 药理作用 EGCG, Tumors, Antitumor mechanism
分类号 TS272.51 [农业科学—茶叶生产加工]
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参考文献44

  • 1Yang CS, Wang H, Li GX, et al. Cancer prevention by tea: Evidence from laboratory studies [J].Pharmacol Res,2011,64 (2):113-122.
  • 2Shimizu M, Shirakami Y, Sakai H, et al. (-)-Epigallocate- chingallate inhibits growth and activation of the VEGF/ VEGFR axis in human colorectal cancer cells [J].Chem Biol Interact, 2010, 185(3):247-252.
  • 3Shimizu M, Adachi S, Masuda M, et al. Cancer ehemopre- vention with green tea catechins by targeting receptor tyro- sine kinases[J]. Mol Nutr Food Res, 2011,55(6):832843.
  • 4庞爱明,阮长耿.绿茶的主要成分表没食子儿茶素没食子酸酯(EGCG)抗血液肿瘤血管新生机制的研究[J].中国血液流变学杂志,2008,18(4):471-473. 被引量：3
  • 5Tudoran O, Soritau O, Balacescu O, et al. Early transcrip- tional pattern of angiogenesis induced by EGCG treatment in cervical tumor cells[J].J Cell Mol Med,2012, 16(3):520- 530.
  • 6Kwak IH, Shin YH,Kim M, et al. Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/ scatter factor-induced tumor cell migration and invasion[J]. Exp Mol Med,2011, 43(2):111120.
  • 7Koh YW, Choi EC, Kang SU, et ah Green tea (-)-epigallo- cateehin-3-gallate inhibits HGF-induced progression in o- ral cavity cancer through suppression of HGF/c-Met [J]. J Nutr Biochem, 2011, 22(11):1074-1083.
  • 8Van Aller GS, Carson JD,Tang W, et al. Epigallocatechin- gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor [J]. Biochem Biophys Res Commun, 2011, 406(2):194-199.
  • 9Cavet ME, Harrington KL, Vollmer TR, et al. Anti-inflam- matory and anti-oxidativeeffects of the greenteapolyphe- nolepigallocatechingallate in humancornealepithelialcells[J]. Mol Vis, 2011, 17:533542.
  • 10Wu LY, De Luca T, Watanabe T, et al. Metabolite modula- tion of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol[J]. Bioehim Biophys Acta, 2011, 1810(8):784- 789.

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茶叶通讯
2012年 第4期

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