血脂正常的冠心病患者血脂、脂蛋白及载脂蛋白关系研究

STUDY OF THE RELATIONSHIP AMONG BLOOD LIPID,LIPOPROTEIN AND APOPROTEIN IN CHD PATIENTS WITH MORMAL SERUM LIPD LEVEL

目的 探讨血脂及载脂蛋白正常的冠心病 (CHD)患者血清血脂、脂蛋白与载脂蛋白相互关系及其检测的临床意义。方法 检测 6 6例血清总胆固醇 (TC)、甘油三脂 (TG)、载脂蛋白 (APO) A1 、B正常的冠心病患者血脂、脂蛋白及载脂蛋白 A1 、B水平 ,并与6 6例健康人进行比较。组内差别采用 t检验。结果 冠心病组 LDL -C/APOA1 、TC/HDL -C及 L DL-C/HDL -C比值水平与对照组比较有显著差异 (P<0 .0 5 )。结论 血清 LDL -C/APOA1 、TC/HDL -C、L DL-C/HDL -C比值水平增高为冠心病的危险因子 ,特别是对血脂、脂蛋白、载脂蛋白正常的冠心病患者。

Objective To study the relationship among blood lipid, lipoprotein and apoprotein in patients suffering from coronary heart disease (CHD) with normal serum lipid level and its clinical significance. Methods Blood lipid and lipoprotein as well as ApoA1 & B of 66 patients with CHD but normal level of serum TC, TG, ApoA1,ApoB and 66 normal subjects for control were detected and analysed statistically by T test.Result The LDL C/ApoA1,TC/LDL C,LDL C/HDL C in the patients were significantly different from those in the normal control group(P<0.05).Conclusions The increase in the ratios of LDL C/ApoA1,TC/LDL C and LDL C/HDL C is a risk factor for coronary heart disease,especially for those patients with normal blood lipid and apoprotein.