糖化低密度脂蛋白与糖尿病并发颈动脉粥样硬化的关系

THE RELATION BETWEEN GLYCOSYLATED LOW DENSITY LIPOPROTEIN AND DIABETES WITH CAROTID ATHEROSCLEROSIS

目的 观察糖化低密度脂蛋白 (Gly-LDL)与糖尿病并发颈动脉粥样硬化 (CAS)的关系。方法 确诊 型糖尿病 (DM2 )并发 CAS32例。对照组 30例。采用微柱亲和层析法测定血浆 Gly-LDL 含量。结果 DM2并发 CAS组 Gly-L DL水平为 (8.89±2 .5 0 ) %。对照组 Gly-LDL水平为 (4.0 5± 1.0 8) %。 DM2并发 CAS组 Gly-L DL水平显著高于对照组 (P<0 .0 1) ,且颈动脉狭窄率与Gly-LDL含量呈正相关 (P<0 .0 1)。结论 Gly-L DL水平与 DM2患者动脉粥样硬化 (AS)形成有密切关系。

Objective To observe the relation between Glycosylated low density lipoprotein(Gly LDL)and diabetes with carotid atherosclerosis(CAS).Methods Thirtytwo type 2 diabetes mellitus(DM2)with CAS patients were diagnosed.Thirty control subjects without the clinical signs of diabetes and AS were chosen.Gly LDL was measured by aminophenylborate gel affinity chromatography.Results The level of plasm Gly LDL was (8.89±2.50)% in DM2 with CAS patients.The level of plasm GLy LDL was (4.05±1.08)% in control subjects.The level of Gly LDL was significantly high in DM2 with CAS group compared with control subjects (P<0.01).There was a significantly positive correlation between the carotid stenotic rate and the level of Gly LDL in DM2 with carotid AS group (P<0.01).Conclusion There was a close relation between the level of Gly LDL and AS of DM2 patlents.